論文・特許

Papers

• Oyama, R. et al. Target sequence of single cells captured by a polymeric microfluidic device. Sci Rep. 15, 29306 (2025)
• Matsumiya, H. et al.  Establishing a Highly Accurate Circulating Tumor Cell Image Recognition System for Human Lung Cancer by Pre-Training on Lung Cancer Cell Lines. Cancers 17(14), 2289 (2025)
• Kanayama, M. et al. Enhanced capture system for mesenchymal‑type circulating tumor cells using a polymeric microfluidic device 'CTC‑Chip' incorporating cell‑surface vimentin. Oncol Rep. 52, 156 (2024)
• Kase, A. et al. Effect of micropost geometry on capture of circulating tumor cells. Journal of Biorheology 37(2), 112-119 (2023)
• Kanayama, M. et al. Prognostic impact of circulating tumor cells detected with the microfluidic "universal CTC-chip" for primary lung cancer. Cancer Sci. 113, 1028-1037 (2022)
• 大永崇　がんのオーダーメイド治療を可能に！血中循環癌細胞を捕捉・解析できるシステムの開発　北陸経済研究、2022.7, 30-31(2022)
• Kanayama, M. et al. Novel circulating tumor cell‑detection chip combining conventional podoplanin and EGFR antibodies for all histological malignant pleural mesothelioma Oncol Lett. 22, 522 (2021)
• Kure, K. et al. Using the polymeric circulating tumor cell chip to capture circulating tumor cells in blood samples of patients with colorectal cancer. Oncol Lett. 19, 2286-2294 (2020)
• Obayashi, K. et al. Initial detection of circulating tumor cells from metastatic prostate cancer patients with a novel small device. Prostate International 7, 131-138 (2019)
• Ishibashi, R. et al. Detection of circulating colorectal cancer cells by a custom microfluid system before and after endoscopic metallic stent placement. Oncol Lett. 18, 6397-6404 (2019)
• Yoneda, K. et al. Detection of circulating tumor cells with a novel microfluidic system in malignant pleural mesothelioma. Cancer Sci. 110, 726-733 (2019)
• Ohnaga, T. et al. Highly efficient capture of cancer cells expressing EGFR by microfluidic methods based on antigen-antibody association. Sci Rep. 8, 12005 (2018)
• Yoneda, K. et al. Capture of mesothelioma cells with 'universal' CTC-chip. Oncol Lett. 15, 2635-2640 (2018)
• 大永崇ほか　リキッドバイオプシー－体液中腫瘍マーカーの検出・解析技術－　シーエムシー出版、288 (2017)
• Chikaishi, Y. et al. EpCAM-independent capture of circulating tumor cells with a 'universal CTC-chip'. Oncol Rep. 37, 77-82 (2017)
• Ohnaga, T. et al. Capture of esophageal and breast cancer cells with polymeric microfluidic devices for CTC isolation. Mol Clin Oncol. 4, 599-602 (2016)
• 長田拓哉ほか　新規血液中浮遊癌細胞（CTC）捕捉システムによる乳癌患者末梢血液中のCTC同定と抗癌剤感受性予測　癌と化学療法、42巻、1240 (2015)
• Ohnaga, T. et al. Polymeric microfluidic devices exhibiting sufficient capture of cancer cell line for isolation of circulating tumor cells. Biomed Microdevices 15, 611-616 (2013)

Patents

• 特許第5802894号　マイクロ流体チップ
• 特許第5799395号　血液中の浮遊癌細胞を捕捉できるマイクロチップ
• 特許第5326089号　機能性を有する微細構造体
• 特許第4714805号　マイクロチップ
• 特許第4418880号　表面にミクロな構造を有する微細構造体