Cytona's technology platform is based on the technology to create resins required for microfluidic devices for bio-applications and enable their micromolding.

The resin is a photocurable resin made of a proprietary blend of monomers that has specific chemical structures (functional groups) that react with biomolecules, allowing the fabricated devices to immobilize antibodies, enzymes, nucleic acids, etc. on their surfaces.

In order to precisely form fine structures, resin molding uses photocuring molding with a silicon mold. This allows devices to be manufactured with high productivity and low cost, providing highly practical products.

Method for forming microstructures

Example of molded microstructure (observed under an electron microscope)

Micropost array

Line and space (depth: 3 ㎛)

Microchannel and reservoir

Microwell array 01

Microwell array 02

Microwell array 03

The polymer CTC chip was developed to selectively capture various cells, including cancer cells, by combining a microfluidic device with an antigen-antibody reaction. The chip is equipped with many fine posts, whose surfaces are coated with molecules (antibodies) that bind to molecules (antigens) specific to the cells to be captured. This allows only those cells to be selectively captured on the surface from the sample flowing through the chip.
There are two technical key points for efficient capture:

• Design and mold the chip structure (post shape, size, arrangement, etc.) to increase the frequency of contact between cells and the chip surface.
• Allows the free selection of antibodies to match the antigens specific to the cells to be captured

Cytona achieves this by using its unique polymer materials and micromolding technology.

Polymer CTC Chip

Cancer cell capture principle

Watch video to see how the cancer cells (moving white dots) are captured